The FEELGOOD company™ Absorption Advantage - Science made simple
Why Absorption Matters
When you take a supplement, what really matters isn’t just what’s on the label — it’s how much your body can actually absorb and use. This concept is known as bioavailability, and it plays a major role in whether a nutrient can deliver real, measurable benefits [1–3].
Many traditional supplements contain ingredients that are difficult for the body to absorb. Even high-quality vitamins and botanicals can pass through the digestive system with limited uptake if they aren’t delivered in the right form [2–5].
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The Problem with Conventional Supplements
Research shows that many common nutrients face challenges such as:
- Poor water solubility
- Difficulty crossing intestinal cell membranes
- Breakdown by stomach acid and digestive enzymes
- Loss during liver metabolism before reaching circulation
Because of these barriers, some supplements may result in low blood levels, even when taken regularly or at higher doses [2–5].
FEELGOOD’s Solution: Absorption-First Nutrition
FEELGOOD Company™ focuses on how nutrients are delivered, not just how much is included. Our formulations use three science-backed strategies designed to help nutrients get into your system more effectively:
- Phospholipid (Phytosome®-style) Complexes
- Liposomal Delivery Systems
- Methylated (Active) Nutrient Forms
Each approach is supported by clinical research and targets a different absorption challenge.
ABSORPTION MATTERS MORE THAN DOSAGE™
ABSORPTION MATTERS MORE THAN DOSAGE™
Phospholipid (Phytosome-Style) Complexes
Helping Botanicals Absorb Better
Many plant compounds — like curcumin and quercetin — don’t dissolve well in the digestive tract, which limits absorption.
Phospholipid complexes bind these plant nutrients to compounds similar to the fats that make up your cell membranes. This makes them easier for your body to absorb and transport [6,7].
What studies show:
A curcumin-phospholipid formulation demonstrated nearly 29-times higher absorption compared to standard curcumin in a human study [7].
Quercetin delivered in a phospholipid complex showed higher blood levels than conventional quercetin [6].
Why this matters:
Better absorption means these botanicals can more effectively support inflammation balance, antioxidant protection, and cellular health.
Liposomal Delivery Systems
Protecting Nutrients Through Digestion
Liposomal supplements wrap nutrients inside tiny lipid (fat-based) bubbles. These structures help protect sensitive nutrients from stomach acid and digestive enzymes, allowing more of the nutrient to reach circulation [8,9].
Liposomes can interact with intestinal cell membranes and be taken up through natural cellular processes, helping nutrients enter the bloodstream more efficiently [8–11].
What studies show:
Liposomal vitamin C produced higher blood and immune-cell vitamin C levels than standard vitamin C [10,11].
Liposomal glutathione significantly increased blood glutathione levels and supported immune markers in human trials [9].
Why this matters:
Improved delivery supports immune health, antioxidant defenses, and cellular resilience — especially for nutrients that are normally hard to absorb.
Methylated (Active) Nutrient Forms
Supporting Individual Genetics
Some vitamins must be converted into active forms before the body can use them. For example, folic acid must be converted into 5-methyltetrahydrofolate (5-MTHF).
Common genetic variations in the MTHFR gene (such as C677T and A1298C) can affect how efficiently this conversion happens [12,13].
Methylated nutrients are already in their active form, meaning they don’t require the same activation steps [14–16].
What studies show:
Supplementation with 5-MTHF effectively supports folate levels and helps reduce homocysteine — a marker linked to cardiovascular health [14–16].
In clinical trials, 5-MTHF performed as well as or better than folic acid in supporting healthy homocysteine levels, depending on the population studied [14,15].
Why this matters:
Providing nutrients in their active forms supports consistent utilization across a wider range of individuals, including those with genetic differences.
What This Means for Your Health
By focusing on absorption and bioavailability, advanced delivery systems can help nutrients better support:
Inflammation balance & antioxidant protection [6,7,9]
Immune health [9–11]
Cardiovascular wellness & homocysteine balance [14–16]
Cognitive and nervous system function [14–16]
Energy metabolism & healthy aging [1–3,8]
A well-balanced diet, exercise and adequate hydration is enough to maintain optimal physical health. FEELGOOD Company™ products are here to fill in nutritional gaps and make optimal health more mainstream with a full spectrum of nutritional support for day-to-day life.
The FEELGOOD Difference
At FEELGOOD Company™, we believe supplements should work with your body, not just pass through it. By combining clinically studied delivery technologies with thoughtfully selected nutrients, our formulations are designed to help your body absorb more, use more, and benefit more.
PHYOTOSOME TECHNOLOGY
Phospholipid Complexation to Enhance Botanical Bioavailability
Phospholipid complexes are formed by non-covalent association of a botanical active with phosphatidylcholine, a major structural component of human cell membranes [6]. This association improves dispersion in gastrointestinal fluids and increases affinity for intestinal membranes.
Human crossover pharmacokinetic studies demonstrate substantially greater absorption of certain polyphenols when delivered in phospholipid or lecithin-based formulations. A lecithin-curcuminoid formulation demonstrated approximately 29-fold higher total curcuminoid exposure compared with an unformulated curcuminoid mixture [7]. Quercetin delivered as a phospholipid complex has also shown improved solubility and higher plasma exposure relative to standard quercetin [6].
These absorption improvements have been associated with clinically relevant outcomes in areas such as inflammatory balance, liver function, and vascular health [6,7].
LIPOSOMAL DELIVERY SYSTEM TECHNOLOGY
Encapsulation Technology for Protected, Targeted, and Enhanced Absorption
Liposomes are phospholipid vesicles capable of encapsulating nutrients within a lipid bilayer. For oral delivery, liposomal systems can improve nutrient stability, protect against gastrointestinal degradation, and facilitate uptake via membrane-interaction and endocytic mechanisms [8,9].
Human studies demonstrate enhanced systemic exposure for select nutrients delivered in liposomal form. Randomized crossover trials have shown greater plasma and leukocyte vitamin C levels following liposomal vitamin C supplementation compared with conventional vitamin C [10,11]. Oral liposomal glutathione has been shown to significantly increase blood glutathione levels and improve immune-related biomarkers in human subjects [9].
These findings support the use of liposomal delivery for nutrients that are otherwise poorly absorbed or rapidly degraded in the digestive tract.
NUTRIENT METHYLATION TECHNOLOGY
Pre-Activated Vitamin Forms for Optimal Bio-efficacy Across Diverse Genetic Profiles
Methylated nutrients are vitamins provided in their biologically active coenzyme forms, such as 5-MTHF (folate), methylcobalamin (vitamin B12), and pyridoxal-5-phosphate (vitamin B6). These forms do not require the same enzymatic activation steps as conventional vitamins [14–16].
Common genetic variants in the MTHFR gene, including C677T and A1298C, influence folate metabolism and homocysteine regulation [12,13]. Clinical trials demonstrate that supplementation with 5-MTHF effectively reduces plasma homocysteine and supports folate status, with outcomes comparable to or, in some contexts, superior to folic acid [14–16].
By providing nutrients in active forms, methylated vitamins support methylation-dependent processes including DNA synthesis, neurotransmitter production, cardiovascular health, detoxification pathways, and mitochondrial energy metabolism.
Clinical Relevance Across Health Categories
Enhanced nutrient delivery has been associated with measurable physiological benefits:
Inflammation & Antioxidant Support: Improved polyphenol and antioxidant exposure supports inflammatory balance and oxidative stress regulation [6,7,9].
Immune Health: Liposomal vitamin C and glutathione increase circulating antioxidant capacity and immune-related biomarkers [9–11].
Cardiovascular Health: Improved polyphenol and folate status supports endothelial function and homocysteine regulation [7,14–16].
Cognitive & Nervous System Function: Methylated B-vitamins support neurotransmitter synthesis and cognitive pathways [14–16].
Mitochondrial & Metabolic Health: Improved nutrient delivery supports energy metabolism and cellular resilience [2,8].
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[2] Vinarov Z, et al. Impact of gastrointestinal tract variability on oral drug absorption. Eur J Pharm Sci. 2021.
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[5] Rein MJ, et al. Barriers to bioavailability of food bioactives. Br J Clin Pharmacol. 2013.
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[8] He H, et al. Adapting liposomes for oral drug delivery. Acta Pharm Sin B. 2019.
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[10] Gopi S, et al. Liposomal vitamin C: enhanced bioavailability in humans. Nutrients. 2021.
[11] Purpura M, et al. Enhanced absorption of vitamin C from liposomal delivery. Nutrients. 2024.
[12] Frosst P, et al. Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency. Am J Hum Genet . 1995
[13] Weisberg I, et al. A second common mutation in MTHFR (A1298C). Am J Hum Genet. 1998.
[14] Venn BJ, et al. Comparison of the effect of low-dose supplementation with l-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study. Am J Clin Nutr. 2003.
[15] Lamers Y, et al. Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women. Am J Clin Nutr. 2004.
[16] Ferrazzi E, et al. Folic acid versus 5- methyl tetrahydrofolate supplementation in pregnancy. Nutrients. 2020.